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Article

Two Cases of CLIPPERS-like Syndrome Sharing a Hypomorphic UNC13D Variant.

Journal of clinical immunology - 4 Mar 2026

Sagawa Hirotaka, Hirata Kosei, Katayama Saori, Shibata Hirofumi, Toyofuku Etsushi, Kaneko Shuya, Katata Yu, Takezawa Yusuke, Uematsu Mitsugu, Onishi Iichiroh, Yamazaki Yuto, Hattori Takaaki, Yamamoto Masahide, Shimizu Masaki, Imai Kohsuke, Yasumi Takahiro, Morio Tomohiro, Yokota Takanori, Sasahara Yoji, Kanegane Hirokazu

Abstract excerpt

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) syndrome is a central nervous system (CNS) inflammatory disease characterized by contrast-enhanced MRI findings of salt-and-pepper-like lesions predominantly affecting the brainstem and cerebellum. We report two patients with CLIPPERS-like brain MRI findings who carried the same missense UNC13D variant in one...

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Identifiers

PMID: 41781714
DOI: 10.1007/s10875-026-01988-1
PMCID: PMC12960380

Genes

UNC13D
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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