Article
Inherited risk factors for thrombotic diseases in children: the genome-wide perspective.
Seminars in thrombosis and hemostasis - 1 Oct 2011
Preuss Christoph, Stoll Monika
Abstract excerpt
As a result of technological advances in the field of high-throughput genomics, there has been a remarkable transition in studying the nature of complex genetic disorders. The genetic analysis of prothrombotic risk factors has shifted from candidate gene to genome-wide association studies (GWAS) in adults. GWAS established a framework in which up to 90% of common genetic variation can be analyzed in a single...
Topics
- Adult
- Anticoagulants
- Child
- Drug Resistance
- Factor V
- Family
- Fibrinogen
- Genome-Wide Association Study
- Humans
- Infant, Newborn
- Methylenetetrahydrofolate Reductase (NADPH2)
- Phenotype
- Risk Factors
- Stroke
- Thrombophilia
- Venous Thrombosis