Article
Characterization of Kidney and Liver Cystic Phenotype Associated with <italic>GANAB</italic> Using Advanced Imaging Biomarkers.
Nephron - 1 Jan 2026
Munairdjy Debeh Fadi George, Bou Antoun Marie Therese, Ghanem Ahmad, Rangarajan Vineetha, Borghol Abdul Hamid, Paul Stefan, Hanna Dana, AlKhatib Bassel, Nader Nay, Shami Besher, Gregory Adriana, Yang Hana, Schauer Rachel S, Zoghby Ziad, Hogan Marie C, Dahl Neera K, Hanna Christian, Kline Timothy L, Harris Peter C, Chebib Fouad T
Abstract excerpt
BACKGROUND: Monoallelic pathogenic variants in GANAB cause autosomal dominant cystic kidney and liver disease, but quantitative imaging phenotypes remain incompletely defined. METHODS: We performed a retrospective study of 16 individuals with GANAB variants and available abdominal imaging. Deep learning-based cyst segmentation quantified kidney and liver volumes and cyst metrics, including height-adjusted total...
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