Article
Risk of Breast Cancer After Ovarian Cancer in Women With a Pathogenic/Likely Pathogenic Variant in BRCA1 or BRCA2.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Apr 2026
Apostol Adriana I, Gronwald Jacek, Cybulski Cezary, Kim Raymond H, Møller Pål, Karlan Beth Y, Bordeleau Louise, Schrader Intan, Ramón Y Cajal Teresa, Pal Tuya, Eisen Andrea, Singer Christian F, Couch Fergus J, Zakalik Dana, Metcalfe Kelly, Olopade Olufunmilayo, Tung Nadine, Fruscio Robert, Foulkes William D, Aeilts Amber, Sun Ping, Lubinski Jan, Narod Steven A, Kotsopoulos Joanne
Abstract excerpt
PURPOSE: BRCA carriers face high risks of developing both breast and ovarian/fallopian tube cancers (hereafter referred to as ovarian). Among BRCA carriers with ovarian cancer, it is not clear whether the risk of breast cancer is sufficiently high that risk-reducing mastectomy should be offered. This study aimed to assess the risk of breast cancer BRCA carriers after a diagnosis of ovarian cancer. METHODS: We...
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