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Article

Tryptophanase disruption promotes insect-bacterium mutualism.

Nature microbiology - 1 Mar 2026

Wang Yayun, Moriyama Minoru, Koga Ryuichi, Oguchi Kohei, Hosokawa Takahiro, Takai Hiroki, Shigenobu Shuji, Nikoh Naruo, Fukatsu Takema

Abstract excerpt

Animal-microorganism symbioses are omnipresent, with both partners often gaining benefits as mutualists. A single mutation in the carbon catabolite repression system in Escherichia coli enables mutualism with the stinkbug Plautia stali. Here we find that this mutation is not present in natural symbioses. Given that the carbon catabolite repression pathway affects the expression of >500 downstream genes, we...

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PMID: 41760926
DOI: 10.1038/s41564-026-02264-z
PMCID: PMC12962977

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