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Article

Collagen and microvascular alterations contribute to neuromuscular degeneration and disease progression in chronic intestinal pseudo-obstruction.

Journal of internal medicine - 1 May 2026

Boschetti Elisa, Neri Irene, Caporali Leonardo, Bonora Elena, Malagelada Carolina, Fiorini Claudio, Ormanbekova Danara, Berghella Alessandro, D'Angelo Roberto, Rinaldi Rita, Caliceti Cristiana, Costanzini Anna, Falconi Mirella, Stanghellini Vincenzo, Ratti Stefano, Manzoli Lucia, Carelli Valerio, De Giorgio Roberto

Abstract excerpt

BACKGROUND: Chronic intestinal pseudo-obstruction (CIPO) is a severe gastrointestinal motility disorder that may be idiopathic or associated with systemic disease. In idiopathic cases, the pathophysiological mechanisms remain poorly defined. Although mutations in angiogenic factors have been reported in mitochondrial forms of CIPO, their role in non-mitochondrial cases is still unclear. OBJECTIVE: To investigate...

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Chronic Disease
Collagen
Hypoxia-Inducible Factor 1, alpha Subunit
Intestinal Pseudo-Obstruction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Thymidine Phosphorylase

Vascular Endothelial Growth Factor A

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Identifiers

PMID: 41755683
DOI: 10.1111/joim.70078
PMCID: PMC13061101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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