Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An ACOT4 Multi-Nucleotide Variant Is Associated with Cardiovascular Risk in Norfolk Island and UK Biobank Cohorts.

Genes - 9 Feb 2026

Meyjes-Brown Jacob W I, Sutherland Heidi G, Tran Kim Ngan, Benton Miles C, Lea Rod A, Griffiths Lyn R

Abstract excerpt

BACKGROUND: Cholesterol imbalances and elevated blood pressure (BP) are closely interrelated risk factors for cardiovascular disease (CVD) and are subject to genetic influences. We sought to identify novel associations between candidate genetic coding variants and CVD traits in our isolated study cohort and validate them in a general population cohort. METHODS: We leveraged the population genetic features of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Biological Specimen Banks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blood Pressure

Share to Cardiovascular Diseases

Share to Cholesterol

Share to Polymorphism, Single Nucleotide

Share to UK Biobank

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 41751589
DOI: 10.3390/genes17020205
PMCID: PMC12940796

Genes

ACOT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An ACOT4 Multi-Nucleotide Variant Is Associated with Cardiovascular Risk in Norfolk Island and UK Biobank Cohorts.PMID 41751589Read ↗

Common and Rare Variants Associated with Cardiometabolic Traits across 98,622 Whole-Genome Sequences in the<i>All of Us</i>Research ProgramSemantic proximity Read ↗

Common and rare variants associated with cardiometabolic traits across 98,622 whole-genome sequences in the All of Us research program.Semantic proximity Read ↗

Analysis of exome-sequenced UK Biobank subjects implicates genes affecting risk of hyperlipidaemia.Semantic proximity Read ↗

Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals.Semantic proximity Read ↗

Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank.Semantic proximity Read ↗

Phenome-wide association study of loci harboring <i>de novo</i> tandem repeat mutations in UK Biobank exomesSemantic proximity Read ↗

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.Semantic proximity Read ↗

Integrative exome sequencing and multi-omics analysis elucidates the regulatory role of rare variants in metabolic syndrome.Semantic proximity Read ↗

Rare Exome Sequence Variants in CLCN6 Reduce Blood Pressure Levels and Hypertension Risk.Semantic proximity Read ↗

Weighted burden analysis of rare coding variants in 470,000 exome-sequenced UK Biobank participants characterises effects on hyperlipidaemia risk.Semantic proximity Read ↗

ASSOCIATION ANALYSIS OF MITOCHONDRIAL HETEROPLASMIC VARIANTS AND CARDIOMETABOLIC TRAITSSemantic proximity Read ↗

Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.