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Article

Unravelling Ovarian Cancer: an analysis of the Influence of LRP1 and PAI1 Genetic Variations.

Biochemical genetics - 1 Oct 2026

Devi Krishna R B, Mathews Sneha Grace, Agarwal Preet, Rani C Elizabeth, Krishnamurthy Nandini, Murali Sanjana, Rani A Lohitha, Joseph Leena Dennis, Rajasekaran Banukeerthana, Mary F Andrea

Abstract excerpt

To assess the potential association between LRP1 (rs715948) and PAI1 (rs2227631, rs1799889) gene variation and ovarian cancer (OC) susceptibility. This study evaluated the genotypic and allelic distributions of LRP1 gene and PAI1 gene variants using Restriction Fragment Length Polymorphism (RFLP) analysis in 134 °C patients and 134 healthy controls. LRP1 (rs715948) showed a significant association with OC risk....

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Topics

Humans
Female
Ovarian Neoplasms
Low Density Lipoprotein Receptor-Related Protein-1
Plasminogen Activator Inhibitor 1
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
Middle Aged
Case-Control Studies
Alleles
Genotype
Adult

Source

Identifiers

PMID: 41729408
DOI: 10.1007/s10528-026-11331-3

Genes

LRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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