Convergence and global molecular epidemiology of Klebsiella pneumoniae plasmids harbouring the iuc3 virulence locus: a population genomic analysis.

doi:10.1016/j.lanmic.2025.101236

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Convergence and global molecular epidemiology of Klebsiella pneumoniae plasmids harbouring the iuc3 virulence locus: a population genomic analysis.

The Lancet. Microbe - 1 Feb 2026

Gibbon Marjorie J, Couto Natacha, Cozens Keira, Habib Samia, Cowley Lauren, Aanensen David M, Corander Jukka, Thorpe Harry A, Hetland Marit A K, Sassera Davide, Merla Cristina, Corbella Marta, Ferrari Carolina, Turner Katy M E, Sirikanchana Kwanrawee, Dulyayangkul Punyawee, Charoenlap Nisanart, Thamlikitkul Visanu, Avison Matthew B, Feil Edward J

Abstract excerpt

BACKGROUND: Klebsiella pneumoniae is an important pathogen of humans and animals. In the past five years, increasing reports of convergent strains that carry both virulence factors and antimicrobial resistance genes (ARGs) have raised serious public health concerns. The aim of this study is to describe the global diversity of plasmids carrying iuc3 (a key virulence factor in K pneumoniae associated with pigs and...

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PMID: 41512896
DOI: 10.1016/j.lanmic.2025.101236

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