Article
Tuning of the RBR1-E2F/DP transcriptional module by the F-box protein FBL17.
Science advances - 20 Feb 2026
Espanet Juliette, He Xiaoning, Pan Ting, Gentric Naomie, Potuschak Thomas, Desvoyes Bénédicte, Hammann Philippe, Chicher Johana, Brik Rim, Lechner Esther, Latrasse David, Pettkó-Szandtner Aladár, Gutierrez Crisanto, Raynaud Cécile, Magyar Zoltán, Benhamed Moussa, Yan Shunping, Noir Sandra, Genschik Pascal
Abstract excerpt
F-box proteins of SCF E3 ligases have been documented to control the abundance of numerous critical regulatory proteins. In Arabidopsis, one of them, F-BOX-LIKE17 (FBL17), stands out for playing a key role in DNA replication, DNA damage, and, more recently, for the control of cell size. FBL17 null mutants exhibit severe cellular defects leading to lethality. However, the molecular mechanisms by which FBL17...
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