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Article

Reasons for and against presymptomatic genetic testing in frontotemporal dementia: a qualitative study.

Human genetics - 16 Feb 2026

Graafland Charlotte H, Seelaar Harro, Panman Jessica L, van Swieten John C, Bunnik Eline M, Donker Kaat Laura

Abstract excerpt

The majority of individuals at 50% risk of carrying a pathogenic variant causing frontotemporal dementia (FTD) chooses not to undergo presymptomatic genetic testing. To explore reasons of individuals at risk of genetic FTD for and against genetic testing, we conducted a secondary analysis of semi-structured interviews with 28 Dutch individuals at risk of genetic FTD: 11 carriers, three non-carriers and 14...

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Identifiers

PMID: 41697408
DOI: 10.1007/s00439-025-02795-1
PMCID: PMC12909385

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