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Mining Differentially Expressed Genes in the Marine Free-Living Flatworm Macrostomum lignano Under Aneuploidy-Driven Ploidy Changes.

Cells - 27 Jan 2026

Zadesenets Kira S, Ershov Nikita I, Bondar Natalya P, Orishchenko Konstantin E, Rubtsov Nikolay B

Abstract excerpt

Whole-genome duplication (WGD) is a powerful evolutionary force, yet the mechanisms by which neopolyploids achieve transcriptomic stability and phenotypic success remain poorly understood. This study investigated the phenotypic and transcriptomic consequences of ploidy changes in the flatworm Macrostomum lignano, a "successful" neopolyploid model. We exploited two established sublines derived from the inbred DV1...

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PMID: 41677612
DOI: 10.3390/cells15030245
PMCID: PMC12896417

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