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Assessment of Esophagogastric Junction Integrity by High-Resolution Manometry Identifies Upright and Recumbent Predominant Reflux Phenotypes.

Neurogastroenterology and motility - 1 Feb 2026

Vespa Edoardo, Barchi Alberto, Altieri Gabriele, Girelli Marina, Ventimiglia Antonio, Centanni Lucia, Lodola Ilaria, Danese Silvio, Passaretti Sandro

Abstract excerpt

BACKGROUND AND AIMS: Esophagogastric junction (EGJ) integrity influences gastroesophageal reflux disease (GERD) pathophysiology, but its association with positional reflux patterns remains unclear. This study evaluated whether upright and recumbent acid exposure differs based on EGJ status on high-resolution manometry (HRM). METHODS: Retrospective study of patients undergoing HRM and 24-h pH-impedance monitoring...

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PMID: 41668426
DOI: 10.1111/nmo.70262

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