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Whole-genome analysis of CVA4 in children with herpangina in two cities of Shandong, China.

Scientific reports - 9 Feb 2026

Ma Wenqing, Dong Zhen, Mou Xiaodong, Zhang Fengtao, Liu Xiaolin, Yu Xiaolin, Wang Jianxing, Kou Zengqiang

Abstract excerpt

Sporadic epidemics of herpangina caused by Coxsackievirus A4 (CVA4) have been reported globally, however, research on CVA4 remains relatively scarce. In this study, 60 Coxsackievirus A4 (CVA4) strains were successfully isolated from 256 throat swab specimens and 50 high-quality complete genome sequences were generated using high-throughput sequencing technology. Phylogenetic analysis based on the VP1 region...

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Identifiers

PMID: 41663706
DOI: 10.1038/s41598-026-39455-x
PMCID: PMC12953577

Genes

C2

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