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Clinical features and outcome of arrhythmogenic cardiomyopathy because of a desmoglein-2 founder variant: A multicenter study.

Heart rhythm - 1 Aug 2026

Fu Bingqi, Chen Zhongli, Chen Zixian, Lin Yubi, Yang Bing, Wang Yunlong, Chen Kangyu, Zhao Xiaoyan, Zhao Xi, Zheng Yingying, Hu Dan, Shi Anteng, Li Zemeng, Hu Yuxiao, Wu Lingmin, Duru Firat, Hua Wei, Chen Liang

Abstract excerpt

BACKGROUND: Desmoglein 2 (DSG2)-associated cardiomyopathy represents a distinct subset of arrhythmogenic cardiomyopathy. A founder variant, NM_001943.5 (DSG2): c.T1592G (p.Phe531Cys), was identified with high frequency in China. OBJECTIVE: The study aimed to describe clinical features and outcomes of this founder variant. METHODS: Individuals with DSG2 c.T1592G (p.Phe531Cys) variants were recruited from 9 centers...

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Arrhythmogenic Right Ventricular Dysplasia
China
Desmoglein 2
DNA
Electrocardiography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Magnetic Resonance Imaging, Cine

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PMID: 41662985
DOI: 10.1016/j.hrthm.2026.01.053

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DSG2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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