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Article

Defining frailty using a modified Fried's Frailty Phenotype in a Southern African context.

PloS one - 1 Jan 2026

Madela E I Y, Gregson C L, Paruk F, Burton A J, Patel R, Wilson H, Habana F, Manyara A M, Mbanjwa B, Gates L, Grundy C, Ward K A, Cassim B

Abstract excerpt

INTRODUCTION: Frailty leads to disability, morbidity, and mortality in older persons. The Fried's Frailty Phenotype (FFP), derived in the American Cardiovascular Health Study (CHS), is widely used around the world to define frailty, but lacks adaptation in African populations. OBJECTIVE: To derive a modified FFP definition which best identifies frailty in a Southern African context. METHODS: A population-based...

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PMID: 41637395
DOI: 10.1371/journal.pone.0340723
PMCID: PMC12872031

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