Retinal microvascular alterations in sickle cell disease: a systematic review and meta-analysis of OCTA findings based on genotype and stages of retinopathy.

doi:10.1007/s00417-025-07083-2

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Retinal microvascular alterations in sickle cell disease: a systematic review and meta-analysis of OCTA findings based on genotype and stages of retinopathy.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie - 1 May 2026

Amanollahi Mobina, Mozafar Mehrdad, Farrokhpour Hossein, Gouravani Mahdi, Samiee Reza, Amiri Fatemeh, Rezaei Saeid, Rasouli Saeid, Jameie Melika, Mozafar Negar, Pour Elias Khalili, Zhang Alice Yang

Abstract excerpt

PURPOSE: Sickle cell disease (SCD) is one of the most prevalent genetic disorders that notably impacts the retinal microvasculature. This study aims to conduct a systematic review and meta-analysis of studies on optical coherence tomography angiography (OCTA) measurements in SCD. METHODS: A systematic search was performed through PubMed and Embase from the earliest record until July 2024. Data extraction was...

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PMID: 41636835
DOI: 10.1007/s00417-025-07083-2

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