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Article

Case Report: A successful case of allogeneic stem cell transplantation for pediatric XMEN characterized by neutropenia.

Frontiers in immunology - 1 Jan 2026

Tian Jieyu, Zheng Jie, Qin Maoquan, Mao Huawei, Zhu Guanghua

Abstract excerpt

XMEN disease (X-linked immunodeficiency with magnesium defect, EBV infection, and neoplasia) is a rare Inborn Error of Immunity (IEI)characterized by impaired magnesium ion transport due to mutations in the MAGT1 gene, which subsequently affects immune cell function. Timely diagnosis and prompt intervention are essential for improving patient outcomes. Allogeneic hematopoietic stem cell transplantation (HSCT)...

Topics

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Cation Transport Proteins
Hematopoietic Stem Cell Transplantation
Infant
Mutation
Neutropenia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transplantation, Homologous

Treatment Outcome

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Identifiers

PMID: 41624006
DOI: 10.3389/fimmu.2026.1687549
PMCID: PMC12851993

Genes

MAGT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Case Report: A successful case of allogeneic stem cell transplantation for pediatric XMEN characterized by neutropenia.PMID 41624006Read ↗

Lymphoma arising in the setting of inborn errors of immunity: A six-case series of XMEN-associated pediatric lymphomaSemantic proximity Read ↗

XMEN-associated Systemic EBV-positive T-cell Lymphoma of Childhood: Report of Two Cases and Literature Review.Semantic proximity Read ↗

Identification of a novel MAGT1 mutation supports a diagnosis of XMEN disease.Semantic proximity Read ↗

Scales of Magt1 Gene: Novel Mutations, Different Presentations.Semantic proximity Read ↗

An Update on XMEN Disease.Semantic proximity Read ↗

X-linked immunodeficiency with magnesium defect, Epstein–Barr virus infection, and neoplasia diseaseSemantic proximity Read ↗

[X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia: report of a family and literature review].Semantic proximity Read ↗

Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN diseaseSemantic proximity Read ↗

MAGT1 gene mutation causes myositis and CD127 expression downregulationSemantic proximity Read ↗

Identification of a novel mutation in MAGT1 and progressive multifocal leucoencephalopathy in a 58-year-old man with XMEN disease.Semantic proximity Read ↗

Genomics of Immune Diseases and New Therapies.Semantic proximity Read ↗

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