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Article

Exploratory genome-wide analysis suggests potential associations of PPP1R12B, FSTL5, G5K3B, and GFRA2 loci with a derived HDL functionality score.

Journal of clinical lipidology - 1 Mar 2026

Braga Ribanna A M, Alvarenga Livia, Aldin Marlene N, Leite Jean Michel R S, Pereira Jaqueline L, Cerqueira Andressa, Fisberg Regina M, Rogero Marcelo M, Sarti Flavia M, Damasceno Nágila R T

Abstract excerpt

BACKGROUND: The size, composition, and functionality of high-density lipoprotein cholesterol (HDL-C) are potential biomarkers for predicting atherosclerosis, representing a major advance in the prevention and treatment of cardiovascular diseases. OBJECTIVE: This study aims to explore HDL-C concentrations and a derived HDL functionality score (HFS), and to investigate suggestive genetic associations in a...

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Source

Identifiers

PMID: 41622043
DOI: 10.1016/j.jacl.2026.01.004

Genes

FSTL5
GFRA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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