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Article

Bile duct tumor thrombus (intraductal polypoid growth)-positive intrahepatic cholangiocarcinoma: clinicopathologic and genomic analysis.

The Journal of pathology - 1 May 2026

Mitsui Ayaka, Esaki Minoru, Nara Satoshi, Arai Yasuhito, Nakamura Hiromi, Shibata Tatsuhiro, Ban Daisuke, Mizui Takahiro, Hiraoka Nobuyoshi

Abstract excerpt

Bile duct tumor thrombus (BDTT), a tumor cluster occupying the luminal space in the large bile duct, is rare in intrahepatic cholangiocarcinoma (iCCA). Most studies on BDTT in iCCA to date are case reports, and the clinicopathological characteristics remain unknown. This study aimed to characterize iCCA with BDTT clinicopathologically and genetically. We analyzed 223 surgically resected iCCA cases, including 102...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41618619
DOI: 10.1002/path.70038

Genes

FGFR2
MUC2
MUC17
ARID1A
BAP1
BRAF
CACNA1A
EPHA2
IDH1
KRAS
MAP3K4
MDM2
MUC1
MUC4
MUC5AC
NF1
NRAS
PIK3CA
PTPRK
RSPO3
SMAD4
TGFBR1
TP53
ZNF717

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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