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Genetic Control of Tissue Remodeling by a Non-Coding SNP in ITGA8 Explains Carotenoid-Based Color Polymorphism in Marine Mollusks.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 May 2026

Wei Xiaohui, Peng Wenzhu, Huang Zekun, Yang Bingye, Wu Yiyu, Han Minzhen, Wang Yi, Peng Bingling, Hu Guosheng, Hong Jiawei, Liu Guijia, Nie Linwei, Gan Yang, Huang Miaoqin, Luo Xuan, You Weiwei, Liu Wen, Ke Caihuan

Abstract excerpt

Biological color polymorphism represents a widespread form of phenotypic diversity in nature; however, the multi-scale regulatory mechanisms of carotenoid-based coloration, from genetic control to cell states and tissue architecture, remain poorly understood. Here, using the orange-muscle giant abalone (Haliotis gigantea) as a model, we demonstrate that a non-coding single nucleotide polymorphism (SNP) in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41603158
DOI: 10.1002/advs.202520527
PMCID: PMC13170236

Genes

ITGA8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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