Recreating viable YYh genotype uncovers the role of CpYYL underlying YY lethality in papaya.

doi:10.1038/s41467-026-68627-6

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Article

Recreating viable YYh genotype uncovers the role of CpYYL underlying YY lethality in papaya.

Nature communications - 24 Jan 2026

Yue Jingjing, Liu Juan, Zeng Qiuxia, Wai Ching Man, Deng Ban, Tong Yihan, Zuo Liping, Xiang Tao, Xie Wangyang, Zhao Xiaobing, Lai Juan, Liao Jingjin, Lai Qingqing, Xu Liangwei, Zhu Yating, He Juan, Zhang Mingjing, Nie Suyue, Lin Zeng, Liang Yanqing, Jiang Shaolian, Chen Xi, Wang Bowei, Huang Yongji, Xu Yi, Nguyen-Edquilang Julie, Ma Yaying, Fumia Nathan, Jones Tyler, Quesada-Rojas Patricia, Mora-Newcomer Eric, Zhang Jisen, Yu Qingyi, Wang Ming-Li, Ming Ray

Abstract excerpt

Papaya is a trioecious species with XX females, XY males, and XYh hermaphrodites. Any combination of Y and Yh chromosomes is lethal. The gene underlying YY lethality is pivotal in the transition from stage 2 to stage 3 in sex chromosome evolution. Here, we identify and functionally validate the YY lethality gene in papaya, CpYYL. Loss of CpYYL function accelerates glycolysis and reduces sucrose accumulation in...

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Identifiers

PMID: 41580421
DOI: 10.1038/s41467-026-68627-6
PMCID: PMC12936061

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