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Article

TFG p.G269V Mutation Disrupts Motor Neuron Function in iPSC-Derived Models via Wnt Signaling Dysregulation.

Journal of neurochemistry - 1 Jan 2026

Mu Zhiqiang, Wang Jielin, Xiao Tian, Chen Kun, Chen Xinyu, Liu Qiurong, Huang Jiahui, Li Yuanbo, Chen Jing, Wu Yuanming, Liu Fangfang

Abstract excerpt

Charcot-Marie-Tooth disease (CMT), an inherited neuropathy characterized by progressive distal muscle weakness and atrophy, is associated with axonal impairment. Although mutations in the TRK-fused gene (TFG) have been linked to both CMT and hereditary spastic paraplegia, their pathogenic mechanisms remain poorly understood. Previously, we have demonstrated that the TFG p.G269V mutation causes progressive muscle...

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PMID: 41572572
DOI: 10.1111/jnc.70359

Genes

TFG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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TFG p.G269V Mutation Disrupts Motor Neuron Function in iPSC-Derived Models via Wnt Signaling Dysregulation.PMID 41572572Read ↗

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