Article
A rare case of double primary lung adenocarcinomas with uncommon complex EGFR G719X and S768I mutations and pleomorphic carcinoma.
Thoracic cancer - 1 Oct 2023
Morimoto Toshiki, Yamasaki Kei, Shingu Tatsuya, Higashi Yasuyuki, Maeda Yukinori, Uryu Takumu, Kubo Naoto, Kawaguchi Takako, Nishida Chinatsu, Yatera Kazuhiro
Abstract excerpt
Epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI)-targeted therapy has emerged as a viable treatment for patients with advanced non-small cell lung cancer with common EGFR mutations. The uncommon G719X and S768I mutations can co-occur as complex mutations in the same tumor. Here we report a case of a 72-year-old male patient with double lung carcinoma, with G719X and S768I complex mutations...
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