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Cancer risk in patients with pulmonary fibrosis and a rare telomere related gene variant.

Respiratory research - 19 Jan 2026

van der Vis Joanne J, Maus Martijn T K, de Bie Charlotte I, van der Smagt Jasper J, Daenen Laura G M, van Oosterhout Matthijs F M, Grutters Jan C, van Moorsel Coline H M

Abstract excerpt

BACKGROUND: Rare telomere related gene (TRG) variants are the cause of telomere biology disorders (TBD), a broad spectrum of age-related diseases, such as pulmonary fibrosis (PF) a disease manifesting at older age. TBD patients are at increased risk of certain types of squamous cell carcinomas and hematological malignancies. However, most studies on cancer incidence in TBDs involved relatively young cohorts in...

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Identifiers

PMID: 41555406
DOI: 10.1186/s12931-025-03469-2
PMCID: PMC12896182

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TRG

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