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Post-transplantation gilteritinib maintenance therapy and therapeutic drug monitoring in pediatric acute myeloid leukemia with FLT3-internal tandem duplication.

Cancer chemotherapy and pharmacology - 20 Jan 2026

Yanagimachi Masakatsu, Iwano Reiko, Keino Dai, Kimizuka Yu, Kurita Daisuke, Hayashi Akiko, Miyagawa Naoyuki, Yokosuka Tomoko, Hamanoue Satoshi, Iwasaki Fuminori, Goto Hiroaki

Abstract excerpt

PURPOSE: FLT3 internal tandem duplication (FLT3-ITD) mutations occur frequently in acute myeloid leukemia (AML) and are associated with high relapse risk. Post-transplant gilteritinib (GILT) maintenance is effective in adults, but pediatric dosing, safety, and the role of therapeutic drug monitoring (TDM) remain undefined. This study evaluated the safety, efficacy, and pharmacokinetic variability of GILT in...

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Identifiers

PMID: 41554949
DOI: 10.1007/s00280-025-04860-y

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Post-transplantation gilteritinib maintenance therapy and therapeutic drug monitoring in pediatric acute myeloid leukemia with FLT3-internal tandem duplication.PMID 41554949Read ↗

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