Genetic and antigenic analysis of the highly pathogenic avian influenza H5N8 virus clade 2.3.4.4b isolated from waterfowl in Egypt during 2022; evidence of brain-specific HA mutations.

Abstract excerpt

1. This study characterised the H5N8 highly pathogenic avian influenza (HPAI) viruses, clade 2.3.4.4b from backyard waterfowl selected from Menoufia governorate during 2022. Genetic and antigenic analysis of H5N8 isolates was performed and the genetic markers for waterfowl brain invasion were analysed by whole genome sequencing.2. Molecular diagnosis of field samples showed that, out of 30 tested waterfowl flocks...

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