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Exome sequencing identifies potential variants linked to cardiovascular disease in Caldas, Colombia: insights from the ORIGEN COLOMBIAN genome project.

Human molecular genetics - 10 Feb 2026

Nieto-Cárdenas Olga A, Candamil-Cortés Mariana S, Uribe-Hurtado Ana L, Morales-Álvarez Edwin D, Orjuela-Rodríguez Marcela

Abstract excerpt

The ORIGEN Project identified, for the first time, variants potentially associated with cardiovascular disease (CVD) in individuals from the Caldas region of Colombia. These findings provide novel insights into the genetic architecture of CVD in an underrepresented population and contribute to closing the knowledge gap in Latin American genomics research. Peripheral blood samples were collected for DNA extraction...

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Source

Identifiers

PMID: 41495918
DOI: 10.1093/hmg/ddaf201

Genes

FBN1
HFE
PERM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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