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Article

Replication of COPD susceptibility loci in a large Chinese elderly population using a validated, multi-setting EHR phenotype.

BMC pulmonary medicine - 5 Jan 2026

Pan Haonan, Wu Peng, Sun Kunyan, Xie Zhixin, Qiu Ziyu, Zhang Qiaoshi, Tian Zijian, Hou Xiangqing, Gao Shiteng, Chen Ying, Zhou Xiaozhou, Cheng Yao, Shao Jian, Wu Benrui, Li Qian, Dong Wanqing, Peng Anjie, Du Yuxuan, Pan Ying, Zhou Kaixin, Xie Tian

Abstract excerpt

BACKGROUND: Validated frameworks for defining chronic obstructive pulmonary disease (COPD) using real-world electronic health records (EHR) data in non-European populations and across multiple healthcare settings and remain limited. This study aimed to develop and validate an EHR-based phenotype for COPD in a large Chinese elderly cohort and assess its utility by replicating known COPD loci. METHODS: We analyzed...

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Identifiers

PMID: 41491456
DOI: 10.1186/s12890-025-04098-7
PMCID: PMC12870439

Genes

AGER
DSP
FAM13A
TGFB2

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