Agitation and anxiety features define a more severe phenotype in unipolar depression.

doi:10.1016/j.psychres.2025.116928

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Agitation and anxiety features define a more severe phenotype in unipolar depression.

Psychiatry research - 1 Mar 2026

Luca Maria, Luca Antonina, Barlati Stefano, Buson Lisa, Menesello Valentina, Magistrali Anna, Silva Rosana Carvalho, Perusi Giulia, Nibbio Gabriele, Bignotti Stefano, Tura Giovanni Battista, Ferri Raffaele, Gennarelli Massimo, Vita Antonio, Souery Daniel, Kasper Siegfried, Zohar Joseph, Montgomery Stuart, Ferentinos Panagiotis, Rujescu Dan, Zanardi Raffaella, Mendlewicz Julien, Minelli Alessandra, Serretti Alessandro

Abstract excerpt

BACKGROUND: Agitated depression, conventionally associated with bipolar disorder, may also constitute a clinically significant subtype within unipolar major depressive disorder (MDD). Nevertheless, the interrelationship between agitation and anxiety symptoms and their clinical implications in unipolar depression remain largely unexamined. METHODS: We examined three large, independent cohorts of patients with MDD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to IDS gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Anxiety

Share to Bipolar Disorder

Share to Major Depressive Disorder

Share to Phenotype

Share to Psychiatric Status Rating Scales

Share to Severity of Illness Index

Share to Suicidal Ideation

Source

Open in PubMed

Identifiers

PMID: 41485399
DOI: 10.1016/j.psychres.2025.116928

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Agitation and anxiety features define a more severe phenotype in unipolar depression.PMID 41485399Read ↗

Characterizing major depression phenotypes by presence and type of psychomotor disturbance in adolescents and young adults.Semantic proximity Read ↗

Agitated depression in bipolar II disorder.Semantic proximity Read ↗

Exploration of Sleep-Centered Clinical Phenotypes to Characterize Anxious and Non-Anxious Major DepressionSemantic proximity Read ↗

Recognition and diagnosis of atypical depression.Semantic proximity Read ↗

Atypical depression is associated with a distinct clinical, neurobiological, treatment response and polygenic risk profileSemantic proximity Read ↗

The Anxious Bipolar Phenotype: Clinical Complexity and Treatment ResistanceSemantic proximity Read ↗

Atypical depressive syndromes in varying definitions.Semantic proximity Read ↗

Association of clinical phenotypes of depression with comorbid conditions, treatment patterns and outcomes: a 10-year region-based cohort study.Semantic proximity Read ↗

Factor structure of the Brief Psychiatric Rating Scale in unipolar depression.Semantic proximity Read ↗

Phenotypic distinctions in depression and anxiety: a comparative analysis of comorbid and isolated cases.Semantic proximity Read ↗

A Preliminary Cross-Sectional Study of Bipolarity and Primary Pharmacotherapy in Long-Term Stable Patients with Major Depressive DisorderSemantic proximity Read ↗

Prevalence and correlates of severe anxiety in patients with first hospitalization for major depressive disorder combined with dyslipidemia: a large sample cross-sectional studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.