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Article

Structure insight into FtsZ function maintaining under acid stress of Streptococcus mutans.

International journal of oral science - 4 Jan 2026

Chen Yuxing, Li Yongliang, Niu Jiahao, Yang Liuchang, Chi Yaqi, Cai Xue, Xin Fengjiao, Zhang Jie, Fang Xianyang, Gao Yiqin, Mondal Manas, Wang Xiaoyan

Abstract excerpt

Understanding the acid resistance mechanism of S. mutans is crucial for preventing dental caries. FtsZ is the core protein for cell division in bacteria that can polymerize into Z-rings and drive cytokinesis. Our previous study revealed that the FtsZ in S. mutans (SmFtsZ) has higher self-assembly and GTPase activity under acidic stress, which may be responsible for acid resistance and cariogenesis of S. mutans....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41484093
DOI: 10.1038/s41368-025-00400-9
PMCID: PMC12764573

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