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Article

Host genetic variation in desmoglein-1 is associated with susceptibility to staphylococcal scalded skin syndrome.

European journal of pediatrics - 2 Jan 2026

Rouva Glykeria, Galanakis Emmanouil, Giormezis Nikolaos, Maraki Sofia, Ladomenou Fani, Tsirigotaki Maria, Martimianaki Georgia, Dimitriou Helen, Krasagakis Konstantinos, Vergadi Eleni

Abstract excerpt

PURPOSE: Staphylococcal scalded skin syndrome (SSSS), caused by Staphylococcus aureus producing exfoliative toxins, develops in only a subset of colonized children, suggesting host genetic factors may influence disease susceptibility. Desmoglein-1 (DSG1), a key adhesion protein in the superficial epidermis, is the primary target of these exfoliative toxins. This study examined whether genetic variation in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41483211
DOI: 10.1007/s00431-025-06710-8

Genes

DSG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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