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Article

Evaluating inbreeding and assessing the risk of outbreeding depression in genetic rescue using whole-genome sequence data.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 2026

Tengstedt Aja Noersgaard Buur, Høye Toke Thomas, Kristensen Torsten Nygaard, Hansen Michael M

Abstract excerpt

Restoring genetic diversity through assisted migration is increasingly recognized as a crucial strategy to counteract inbreeding depression and boost genetic variation in small and fragmented populations yet concerns about outbreeding depression often hinder its application. We propose a genomics-informed update to an existing framework enabling a more precise assessment of outbreeding depression risk and genetic...

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PMID: 41461030
DOI: 10.1073/pnas.2526216122
PMCID: PMC12773729

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