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A targeted mutation in ICP8 attenuates duck plague virus by disrupting replication and proposes a vaccine strategy.

Poultry science - 1 Feb 2026

Wu Ying, Sun Anyang, Zhan Haichuan, Liang Zhiyuan, Yang Qiqi, Wang Mingshu, Liu Mafeng, Chen Shun, Jia Renyong, Yang Qiao, Tian Bin, Ou Xumin, Wu Zhen, Huang Juan, Sun Di, Zhu Dekang, Zhao Xin-Xin, Zhang Shaqiu, He Yu, Cheng Anchun

Abstract excerpt

Controlling duck plague (DP) is essential for waterfowl health and industry productivity. The herpesviral single-stranded DNA-binding protein ICP8 is essential for replication compartment assembly, yet its exploitation for vaccine development in avian herpesviruses is limited. In this study, we generated two ICP8 mutants (H825A and F829A/P830A) in duck plague virus (DPV) via BAC-based homologous recombination....

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Identifiers

PMID: 41435706
DOI: 10.1016/j.psj.2025.106319
PMCID: PMC12800516

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