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Article

From Pulse to Phenotype: Sleep Apnea Endotyping for Polygraphy via Oximeter-Derived Autonomic Arousal.

Chest - 1 May 2026

Strassberger Christian, Hedner Jan, Sands Scott A, Zou Ding, Grote Ludger

Abstract excerpt

BACKGROUND: Understanding the underlying cause of OSA in the individual patient, referred to as pathophysiologic endotyping, is essential for personalized care. The current classification of these traits from routine sleep recordings relies on manually scored arousals from sleep. Automating this process could widen the applicability of endotyping. RESEARCH QUESTION: Can analyzing autonomic variability, derived...

Topics

Humans
Male
Polysomnography
Female
Oximetry
Middle Aged
Arousal
Photoplethysmography
Phenotype
Adult
Sleep Apnea, Obstructive
Electroencephalography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Autonomic Nervous System

Heart Rate

Sleep Apnea Syndromes

Source

Open in PubMed Open full text

Identifiers

PMID: 41421575
DOI: 10.1016/j.chest.2025.12.005
PMCID: PMC13197968

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-41421575-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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