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Article

Assessing the Sensitivity of Nested PCR Followed by Direct Sequencing on Exosomal DNA for EGFR Mutation Detection in NSCL

Iranian biomedical journal - 1 Jul 2024

Jahani Mohammad Mehdi, Mashayekhi Parisa, Omrani Mir Davood, Khosravi Adnan, Ali Dehghanifard, Azad Manjiri Sanam, Zahraei Mahyar, Mabani Maryam, Seifi Sharareh, Salimi Babak, Rostami Parsa

Abstract excerpt

Background: Early and minimally invasive detection of epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) patients is a promising tool to select patients for targeted therapy in order to improve their prognosis. This study aimed to identify a sensitive, cost-effective, and easily accessible noninvasive method for detecting the EGFR-targetable mutations in the plasma exosomal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39289877
DOI: 10.61186/ibj.4289
PMCID: PMC11444484

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