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Article

Distinct clinical phenotypes of pediatric Obsessive-Compulsive Disorder with and without neurodevelopmental disorders: evidence for a neurodevelopmental continuum.

Journal of neurodevelopmental disorders - 17 Dec 2025

D'Aiello Barbara, Pontillo Maria, Demaria Francesco, Di Luzio Michelangelo, Di Vincenzo Cristina, Bertoncini Ilaria, Villani Valeria, Menghini Deny, Vicari Stefano

Abstract excerpt

This study aimed to investigate clinical, demographic, and psychopathological differences between pediatric patients with obsessive-compulsive disorder (OCD) with and without comorbid neurodevelopmental disorders (NDDs), focusing on symptom presentation, comorbidities, and functional outcomes. A total of 121 drug-naïve children and adolescents with recent-onset OCD (66 with comorbid NDDs and 55 without) were...

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PMID: 41408159
DOI: 10.1186/s11689-025-09665-x
PMCID: PMC12821292

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