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More than one species of the naked mole-rat, a new biomedical model.

Communications biology - 9 Dec 2025

Uhrová Michaela, Mikula Ondřej, Bryja Josef, Frýdlová Petra, Zemlemerova Elena D, Elmi Hassan S A, Štolhoferová Iveta, Tymlová Veronika, Maštera Václav, Frynta Daniel, Lavrenchenko Leonid A, Šumbera Radim

Abstract excerpt

The naked mole-rat Heterocephalus, a hairless, subterranean rodent from the Horn of Africa, has attracted scientific interest due to its cooperative breeding, poikilothermy, longevity, resistance to cancer, and tolerance to pain and hypoxia, among others. Genomic analyses of H. glaber, traditionally considered a single species, reveal three highly divergent lineages. One of these, identified as H. phillipsi...

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PMID: 41365994
DOI: 10.1038/s42003-025-09338-4
PMCID: PMC12808700

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