Article
Cardiac rhabdomyomas in tuberous sclerosis complex: clinical manifestations and genotype correlations.
BMC pediatrics - 9 Dec 2025
Praticò Andrea Domenico, Lo Bianco Manuela, Laganà Andrea, Di Napoli Claudia, Salafia Stefania, Sciacca Pietro, Polizzi Agata, Ruggieri Martino
Abstract excerpt
BACKGROUND: Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder characterized by hamartoma formation in multiple organs, including the heart. Cardiac rhabdomyomas (CRs) are the most common cardiac tumors in infancy and occur in up to 80% of individuals with TSC. While CRs often regress spontaneously, their clinical impact varies, particularly concerning arrhythmias and obstructive...
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