A mitochondria-related gene-based signature predicts pancreatic ductal adenocarcinoma clinical outcome and revealed CAMK2A/THEM4 regulates progression phenotypes and mitophagy in vivo and in vitro.

doi:10.1186/s12967-025-07456-5

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Article

A mitochondria-related gene-based signature predicts pancreatic ductal adenocarcinoma clinical outcome and revealed CAMK2A/THEM4 regulates progression phenotypes and mitophagy in vivo and in vitro.

Journal of translational medicine - 6 Dec 2025

Nie Gang, Zhu Zhongfei, Huang Jing, Shi Xiaohan, Yin Xiaoyi, Li Gang, Jin Gang

Abstract excerpt

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with limited available prognostic tools. There is a need to develop robust molecular signatures to improve risk stratification and identify potential therapeutic targets. METHODS: A 12-gene mitochondrial-related prognostic signature was developed using machine learning. The performance was compared with signatures developed using...

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Topics

Humans
Carcinoma, Pancreatic Ductal
Animals
Mitochondria
Pancreatic Neoplasms
Calcium-Calmodulin-Dependent Protein Kinase Type 2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Disease Progression

Cell Line, Tumor

Mitophagy

Gene Expression Regulation, Neoplastic

Phenotype

Prognosis

Mice

Gene Expression Profiling

Female

Source

Open in PubMed Open full text

Identifiers

PMID: 41353164
DOI: 10.1186/s12967-025-07456-5
PMCID: PMC12798084

Genes

THEM4
CAMK2A

Provenance

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