Article
Rationale and Design of the HeartShare/AMP-HF Deep Phenotyping Study to Improve Understanding of Heart Failure With Preserved Ejection Fraction.
JACC. Heart failure - 1 Dec 2025
Borlaug Barry A, Chirinos Julio A, Lewis Gregory D, Redfield Margaret M, Bertoni Alain G, Cadeiras Martin, Chiamvimonvat Nipavan, Desai Akshay S, Givertz Michael M, Kass David A, Khan Sadiya S, Kitzman Dalane W, López Javier E, Rasmussen-Torvik Laura J, Sharma Kavita, Solomon Scott D, Goodpaster Bret, Sparks Lauren, Olgin Jeffrey, Arnaout Rima, Mylavarapu Uma, Alagna Laura, Luo Yuan, Wong Renee, Desvigne-Nickens Patrice, Tinsley Emily, Kamphaus Tania N, Taylor Jennifer L, Jones Melissa A, Jessup Mariell, Schaper Steffen, Chutnow William A, Shah Svati H, Butler Javed, Sachdev Vandana, Shah Sanjiv J
Abstract excerpt
Heart failure with preserved ejection fraction (HFpEF) has risen to become the most common form of heart failure (HF) worldwide. The pathophysiology of HFpEF is complex and intimately tied to cardiac-metabolic-kidney abnormalities, spanning cardiac, vascular, and noncardiovascular organ systems. Large-scale prospective phenotyping studies that comprehensively examine these abnormalities in the same patient are...
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