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Article

Sinonasal DICER1‑mutated embryonal-like (botryoid-like) rhabdomyosarcoma in an adult: report of the first case.

Virchows Archiv : an international journal of pathology - 1 Jun 2026

Rito Miguel, Fernandes Sofia, Stoehr Robert, Agaimy Abbas

Abstract excerpt

The DICER1 gene, essential for microRNA biogenesis and posttranscriptional gene regulation, has been implicated in a variety of benign and malignant neoplasms, particularly within the context of the DICER1-related tumor predisposition syndrome. While DICER1-associated rhabdomyosarcomas (RMS) are predominantly documented in the genitourinary tract, we present the first case of a DICER1-mutated embryonal-like...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41335141
DOI: 10.1007/s00428-025-04358-1
PMCID: PMC13264571

Genes

DICER1
FOXO1
KRAS
MAML3
PAX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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