Rare coding mutations in the glucagon-like peptide-2 pathway are associated with increased risk of binge eating disorders.

Abstract excerpt

BACKGROUND: We have previously reported that patients with a history of binge eating disorder or bulimia nervosa are more likely to have rare, damaging mutations in glucagon-like peptide 1 and glucagon-like peptide 1 receptor. Little is known about the role of the closely related glucagon-like peptide 2 (GLP-2) pathway in regulation of feeding behaviors. RESULTS: The 2-162144091-T-C single nucleotide polymorphism...

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• Bulimia
• Child
• Databases, Genetic
• Exome Sequencing
• Metabolic Networks and Pathways