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Article

Phylogenetic and biochemical analysis of the evolution and interdomain modularity of bifunctional L-fucokinase/GDP-fucose pyrophosphorylases.

The Journal of biological chemistry - 1 Dec 2025

Smith Nicholas T, Hodgins Autumn J, Boddington Marie E, Capicciotti Chantelle J, diCenzo George C, Howe Graeme W

Abstract excerpt

L-fucokinase (FUK) and GDP-fucose pyrophosphorylase (GFPP) salvage free L-fucose and synthesize the valuable nucleotide-sugar GDP-L-fucose (GDP-Fuc). Some organisms express these enzymes as one bifunctional polypeptide called L-fucokinase/GDP-fucose pyrophosphorylase (FKP), which has attracted attention for use in the chemoenzymatic synthesis of GDP-Fuc. Despite the documented use of the FKP from Bacteroides...

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Alanine
Bacterial Proteins
Bacteroidetes
Conserved Sequence
Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleotidyltransferases

Phosphotransferases (Alcohol Group Acceptor)

Protein Domains

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Identifiers

PMID: 41237909
DOI: 10.1016/j.jbc.2025.110937
PMCID: PMC12732313

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