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Article

Non-genetic factors and their impact on severity of inherited cardiomyopathies: Tipping the balance.

Trends in cardiovascular medicine - 1 May 2026

Sweeting Joanna, Stafford Fergus, Hespe Sophie, Butters Alexandra, Ingles Jodie

Abstract excerpt

Inherited cardiomyopathies are a diverse group of diseases with overlapping clinical features and genetic basis. Once thought to be primarily monogenic diseases, it is now known that disease severity and penetrance can be impacted by both genetic and non-genetic factors, such as comorbidities. Inherited cardiomyopathies include hypertrophic (HCM), dilated (DCM), arrhythmogenic (ACM) and restrictive...

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Identifiers

PMID: 41237873
DOI: 10.1016/j.tcm.2025.11.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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