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Article

Ginsenoside Rh2 as a novel PIN1 inhibitor disrupting the cancer stem cell-like phenotype in non-small cell lung cancer.

Journal of translational medicine - 10 Nov 2025

Liu Xiyu, Mao Zijun, Yang Jinglin, Zhu Qianqian, Dong Xinyi, Huang Gang, Shen Xizhong, Zhang Lian, Yang Hao

Abstract excerpt

BACKGROUND: The widespread issue of drug resistance remains a major obstacle in the treatment of lung cancer, particularly non-small cell lung cancer (NSCLC), making the development of novel adjuvant therapeutic strategies an urgent priority. Cancer stem cells (CSCs) are key drivers of drug resistance and metastasis, and the development of therapies targeting CSCs holds potential to overcome resistance to...

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Source

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Identifiers

PMID: 41214647
DOI: 10.1186/s12967-025-07318-0
PMCID: PMC12604370

Genes

PIN1
PGK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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