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Article

Physical Activity and Cardiovascular Outcomes in Phenotype-Negative Cardiomyopathy Variant Carriers.

JAMA cardiology - 1 Jan 2026

Ajufo Ezimamaka, Kany Shinwan, Jurgens Sean J, Churchill Timothy W, Guseh J Sawalla, Aragam Krishna G, Nauffal Victor, Pirruccello James P, Choi Seung Hoan, Lakdawala Neal K, Ho Carolyn Y, Ellinor Patrick T, Khurshid Shaan

Abstract excerpt

Importance: Exercise may lead to disease progression and higher risk of sudden death in individuals with genetic cardiomyopathies, but the effects of exercise among individuals carrying a cardiomyopathy-associated variant without clinical manifestations (G+P-) are unclear. Objective: To examine whether the effects of moderate to vigorous physical activity (MVPA) on cardiovascular (CV) outcomes, cardiac structure...

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Identifiers

PMID: 41205222
DOI: 10.1001/jamacardio.2025.4466
PMCID: PMC12596747

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