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Article

Transformation of Thyroid Eye Disease Phenotype Following Teprotumumab Treatment.

Ophthalmic plastic and reconstructive surgery - 1 Jan 2026

Shabto Julie M, Stevens Shanlee, Gregerson Celestine, Kazim Michael

Abstract excerpt

The authors report a case of a phenotypic shift of thyroid eye disease following treatment with teprotumumab. A 35-year-old female nonsmoker with Graves disease developed mild type I thyroid eye disease featuring unilateral lid retraction and was treated with teprotumumab. Following completion of treatment, a reactivation was associated with progression to severe type II phenotype, with marked extraocular muscle...

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PMID: 41196136
DOI: 10.1097/IOP.0000000000003110

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