Procoagulant phenotype of virus-infected pericytes is associated with portal thrombosis and intrapulmonary vascular dilations in fatal COVID-19.

doi:10.1016/j.jhep.2024.06.014

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Article

Procoagulant phenotype of virus-infected pericytes is associated with portal thrombosis and intrapulmonary vascular dilations in fatal COVID-19.

Journal of hepatology - 1 Nov 2024

Cadamuro Massimiliano, Lasagni Alberto, Radu Claudia Maria, Calistri Arianna, Pilan Matteo, Valle Clarissa, Bonaffini Pietro Andrea, Vitiello Adriana, Toffanin Serena, Venturin Camilla, Friòn-Herrera Yahima, Sironi Sandro, Alessio Maria Grazia, Previtali Giulia, Seghezzi Michela, Gianatti Andrea, Strazzabosco Mario, Strain Alastair J, Campello Elena, Spiezia Luca, Palù Giorgio, Frigo Anna Chiara, Tosoni Antonella, Nebuloni Manuela, Parolin Cristina, Sonzogni Aurelio, Simioni Paolo, Fabris Luca

Abstract excerpt

BACKGROUND & AIMS: The underlying mechanisms and clinical impact of portal microthrombosis in severe COVID-19 are unknown. Intrapulmonary vascular dilation (IPVD)-related hypoxia has been described in severe liver diseases. We hypothesised that portal microthrombosis is associated with IPVD and fatal respiratory failure in COVID-19. METHODS: Ninety-three patients who died from COVID-19 were analysed for portal...

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PMID: 38908437
DOI: 10.1016/j.jhep.2024.06.014

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