Systematic analysis of nutrient-microbiome interactions and their effects on host phenotypes in Drosophila.

Abstract excerpt

Diet and the gut microbiome are interconnected forces shaping host physiology and behavior. However, disentangling their independent and combined effects on phenotypic variation remains a major challenge. Here, we systematically assessed 120 combinations of nutrient and microbiome conditions to evaluate their effects on Drosophila melanogaster phenotypes. By varying dietary yeast-to-sucrose ratios (Y:S) and...

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